UNDERSTANDING THE PATHOGENESIS AND MANAGEMENT OF AUTOIMMUNE HYPERTHYROIDISM
Abstract
Objectives: Autoimmune hyperthyroidism, also known as Graves' disease, is a commonly diagnosed endocrine disorder resulting from the overstimulation of the thyroid gland by antibodies directed against the thyroid-stimulating hormone receptor (TSHR). The autoantibodies, known as thyroid-stimulating immunoglobulins (TSI), bind to the TSHR, leading to the excessive production of thyroid hormones, primarily triiodothyronine (T3) and thyroxine (T4). This thesis aims to provide a comprehensive review of the pathogenesis and management of autoimmune hyperthyroidism.
References
LITERATURE:
"Endocrinology: An Integrated Approach" by Stephen Nussey and Saffron Whitehead.
"The Endocrine System: An Integrated Approach" by Michael Hill.
Clinical Endocrinology and Diabetes Mellitus" by Ramzi Ajjan.
Contemporary Endocrinology" edited by Ashley Grossman.